› 4iw2

X-ray diffraction
2.41Å resolution

HSA-glucose complex

Released:
DOI: 10.2210/pdb4iw2/pdb
PDB entry 4iw2 coloured by chain, front view.
PDB entry 4iw2 coloured by chain, side view.
PDB entry 4iw2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of ring-opening reaction of glucose by human serum albumin.
Wang Y, Yu H, Shi X, Luo Z, Lin D, Huang M
J Biol Chem 288 15980-7 (2013)
PMID: 23592780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

3 bound ligands:
Ligand GLO 1 x GLO
Ligand GLC 1 x GLC
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 57.149Å b: 87.055Å c: 58.534Å
α: 90° β: 102.57° γ: 90°
R-values:
R R work R free
0.254 0.242 0.307
Expression system: Komagataella pastoris

Quick links

Citations

7 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
6 more

6 mentions without citation

Structural mechanism of ring-opening reaction of glucose by human serum albumin.
Wang et al. (2013)
5 more