4ivd Summary

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JAK1 kinase (JH1 domain) in complex with compound 34

The structure was published by Zak, M., Hurley, C.A., Ward, S.I., et al., Xiao, Y., Yang, J., and Kulagowski, J.J., in 2013 in a paper entitled "Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.93 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase JAK1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK1 P23458 (854-1154) (JAK1_HUMAN)search Homo sapienssearch < 90% 302 96%
B Tyrosine-protein kinase JAK1 P23458 (854-1154) (JAK1_HUMAN)search Homo sapienssearch < 90% 302 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23458 (854 - 1154) Tyrosine-protein kinase JAK1 Homo sapiens

Chain Sequence family (Pfam)
A, B Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P23458) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch