spacer JAK1 kinase (JH1 domain) in complex with the inhibitor (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE
UniProt
Accession P23458search
Name JAK1_HUMAN
Keywords Acetylation, Polymorphism, Reference proteome, SH2 domain, Transferase, 3D-structure, Nucleotide-binding, Tyrosine-protein kinase, Phosphoprotein, Kinase, Repeat, ATP-binding, Complete proteome, Membrane
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Polymers A B
 
Enzyme nomenclature
EC number 2.7.10.2 ExPASy BRENDA search
Polymers B, A
Name non-specific protein-tyrosine kinase
Comment Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families.
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