4iva Summary

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JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE

The structure was published by Zak, M., Hurley, C.A., Ward, S.I., et al., Xiao, Y., Yang, J., and Kulagowski, J.J., in 2013 in a paper entitled "Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase JAK2. This molecule has the UniProt identifier O60674 (JAK2_HUMAN)search. The sample contained 300 residues which is < 90% of the natural sequence. Out of 300 residues 292 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK2 O60674 (833-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 300 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60674 (833 - 1132) Tyrosine-protein kinase JAK2 Homo sapiens

Chain Sequence family (Pfam)
A Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (O60674) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch