spacer JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE
UniProt
Accession O60674search
Name JAK2_HUMAN
Keywords Nucleotide-binding, Nucleus, Proto-oncogene, Phosphoprotein, Membrane, Complete proteome, Tyrosine-protein kinase, Polymorphism, Kinase, Repeat, 3D-structure, Reference proteome, Immunity, ATP-binding, Chromatin regulator, SH2 domain, Cytoplasm, Chromosomal rearrangement, Disease mutation, Adaptive immunity, Innate immunity, Transferase
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Polymers A
 
Enzyme nomenclature
EC number 2.7.10.2 ExPASy BRENDA search
Polymers A
Name non-specific protein-tyrosine kinase
Comment Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families.
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