4ith Summary

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Crystal structure of RIP1 kinase in complex with necrostatin-1 analog

The structure was published by Xie, T., Peng, W., Liu, Y., et al., Degterev, A., Yuan, J., and Shi, Y., in 2013 in a paper entitled "Structural Basis of RIP1 Inhibition by Necrostatins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Receptor-interacting serine/threonine-protein kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor-interacting serine/threonine-protein kinase 1 Q13546 (1-294) (RIPK1_HUMAN)search Homo sapienssearch < 90% 294 91%
B Receptor-interacting serine/threonine-protein kinase 1 Q13546 (1-294) (RIPK1_HUMAN)search Homo sapienssearch < 90% 294 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13546 (1 - 294) Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q13546) protein phosphorylationsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch