Structure analysis

Crystal structure of RIP1 kinase in complex with necrostatin-1 analog

X-ray diffraction
2.25Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11960.21 Å2
Buried surface area: 948.57 Å2
Dissociation area: 67.11 Å2
Dissociation energy (ΔGdiss): -1.6 kcal/mol
Dissociation entropy (TΔSdiss): 1.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171747
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 12769.24 Å2
Buried surface area: 863.07 Å2
Dissociation area: 63.08 Å2
Dissociation energy (ΔGdiss): -1.74 kcal/mol
Dissociation entropy (TΔSdiss): 1.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171747

Macromolecules

Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13546 (Residues: 1-294; Coverage: 44%)
Gene names: RIP, RIP1, RIPK1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:

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