4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch ER overload responsesearch positive regulation of protein bindingsearch negative regulation of protein bindingsearch peptidyl-serine phosphorylationsearch regulation of microtubule-based processsearch Wnt signaling pathwaysearch response to lithium ionsearch rhythmic processsearch re-entry into mitotic cell cyclesearch negative regulation of neuron projection developmentsearch phosphorylationsearch negative regulation of apoptotic processsearch protein autophosphorylationsearch fat cell differentiationsearch establishment of cell polaritysearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch negative regulation of dendrite morphogenesissearch cellular response to heatsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch positive regulation of peptidyl-threonine phosphorylationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch protein export from nucleussearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch establishment or maintenance of cell polaritysearch cellular response to interleukin-3search multicellular organismal developmentsearch epidermal growth factor receptor signaling pathwaysearch innate immune responsesearch protein localization to microtubulesearch positive regulation of protein complex assemblysearch regulation of cellular response to heatsearch myoblast fusionsearch cellular response to mechanical stimulussearch carbohydrate metabolic processsearch axonogenesissearch positive regulation of canonical Wnt signaling pathwaysearch hippocampus developmentsearch axon guidancesearch negative regulation of MAP kinase activitysearch negative regulation of neuron maturationsearch positive regulation of cell-matrix adhesionsearch superior temporal gyrus developmentsearch negative regulation of NFAT protein import into nucleussearch negative regulation of cardiac muscle hypertrophysearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of axon extensionsearch response to drugsearch phosphatidylinositol-mediated signalingsearch circadian rhythmsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch regulation of gene expression by genetic imprintingsearch Fc-epsilon receptor signaling pathwaysearch cell differentiationsearch organ morphogenesissearch cell migrationsearch positive regulation of apoptotic processsearch negative regulation of signal transductionsearch glycogen metabolic processsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch nervous system developmentsearch negative regulation of glycogen biosynthetic processsearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch fibroblast growth factor receptor signaling pathwaysearch regulation of neuronal synaptic plasticitysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of neuron projection developmentsearch positive regulation of stem cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch myotube differentiationsearch hypermethylation of CpG islandsearch positive regulation of protein catabolic processsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein bindingsearch ionotropic glutamate receptor bindingsearch kinase activitysearch protein kinase bindingsearch protein kinase A catalytic subunit bindingsearch nucleotide bindingsearch NF-kappaB bindingsearch tau protein bindingsearch tau-protein kinase activitysearch beta-catenin bindingsearch transferase activitysearch protein kinase activitysearch p53 bindingsearch RNA polymerase II transcription factor bindingsearch ubiquitin protein ligase bindingsearch integrin bindingsearch transferase activity, transferring phosphorus-containing groupssearch beta-catenin destruction complexsearch cytosolsearch plasma membranesearch membranesearch centrosomesearch nucleussearch cytoplasmsearch neuronal cell bodysearch membrane-bounded organellesearch growth conesearch perinuclear region of cytoplasmsearch protein complexsearch ribonucleoprotein complexsearch membrane raftsearch dendritic spinesearch cell bodysearch dendritic shaftsearch nucleoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch