4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch negative regulation of cardiac muscle hypertrophysearch Wnt signaling pathwaysearch regulation of gene expression by genetic imprintingsearch re-entry into mitotic cell cyclesearch multicellular organismal developmentsearch peptidyl-serine phosphorylationsearch innate immune responsesearch fat cell differentiationsearch epidermal growth factor receptor signaling pathwaysearch cell migrationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch establishment or maintenance of cell polaritysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of peptidyl-threonine phosphorylationsearch carbohydrate metabolic processsearch ER overload responsesearch nervous system developmentsearch negative regulation of apoptotic processsearch negative regulation of MAP kinase activitysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch cell differentiationsearch negative regulation of protein bindingsearch positive regulation of stem cell differentiationsearch fibroblast growth factor receptor signaling pathwaysearch response to lithium ionsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch organ morphogenesissearch circadian rhythmsearch positive regulation of protein complex assemblysearch establishment of cell polaritysearch cellular response to interleukin-3search neurotrophin TRK receptor signaling pathwaysearch negative regulation of dendrite morphogenesissearch regulation of microtubule-based processsearch protein localization to microtubulesearch positive regulation of apoptotic processsearch negative regulation of signal transductionsearch positive regulation of protein bindingsearch Fc-epsilon receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch negative regulation of neuron projection developmentsearch axonogenesissearch phosphorylationsearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch superior temporal gyrus developmentsearch negative regulation of glycogen biosynthetic processsearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch response to drugsearch protein export from nucleussearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch rhythmic processsearch regulation of neuronal synaptic plasticitysearch cellular response to mechanical stimulussearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch axon guidancesearch myoblast fusionsearch positive regulation of peptidyl-serine phosphorylationsearch myotube differentiationsearch glycogen metabolic processsearch positive regulation of protein catabolic processsearch hypermethylation of CpG islandsearch negative regulation of neuron maturationsearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch protein bindingsearch ionotropic glutamate receptor bindingsearch kinase activitysearch tau protein bindingsearch transferase activitysearch tau-protein kinase activitysearch beta-catenin bindingsearch protein kinase A catalytic subunit bindingsearch integrin bindingsearch NF-kappaB bindingsearch protein kinase bindingsearch nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch p53 bindingsearch ubiquitin protein ligase bindingsearch transferase activity, transferring phosphorus-containing groupssearch beta-catenin destruction complexsearch growth conesearch cytosolsearch cytoplasmsearch membranesearch plasma membranesearch protein complexsearch centrosomesearch nucleussearch membrane raftsearch ribonucleoprotein complexsearch membrane-bounded organellesearch dendritic spinesearch perinuclear region of cytoplasmsearch cell bodysearch dendritic shaftsearch neuronal cell bodysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch