4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch establishment of cell polaritysearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch negative regulation of cardiac muscle hypertrophysearch organ morphogenesissearch fat cell differentiationsearch myoblast fusionsearch peptidyl-serine phosphorylationsearch innate immune responsesearch negative regulation of apoptotic processsearch axonogenesissearch negative regulation of MAP kinase activitysearch hypermethylation of CpG islandsearch glycogen metabolic processsearch ER overload responsesearch myotube differentiationsearch protein localization to microtubulesearch epidermal growth factor receptor signaling pathwaysearch cellular response to interleukin-3search cell migrationsearch positive regulation of protein complex assemblysearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of neuron projection developmentsearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch re-entry into mitotic cell cyclesearch Wnt signaling pathwaysearch negative regulation of protein bindingsearch negative regulation of neuron maturationsearch nervous system developmentsearch multicellular organismal developmentsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch phosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch extrinsic apoptotic signaling pathway in absence of ligandsearch regulation of gene expression by genetic imprintingsearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch superior temporal gyrus developmentsearch protein export from nucleussearch negative regulation of dendrite morphogenesissearch Fc-epsilon receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch regulation of neuronal synaptic plasticitysearch cellular response to mechanical stimulussearch carbohydrate metabolic processsearch response to drugsearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch establishment or maintenance of cell polaritysearch circadian rhythmsearch regulation of microtubule-based processsearch positive regulation of protein bindingsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch cell differentiationsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of glycogen biosynthetic processsearch positive regulation of protein catabolic processsearch negative regulation of signal transductionsearch positive regulation of apoptotic processsearch positive regulation of stem cell differentiationsearch axon guidancesearch response to lithium ionsearch rhythmic processsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch tau-protein kinase activitysearch transferase activitysearch beta-catenin bindingsearch kinase activitysearch tau protein bindingsearch protein kinase A catalytic subunit bindingsearch NF-kappaB bindingsearch protein kinase bindingsearch nucleotide bindingsearch integrin bindingsearch ionotropic glutamate receptor bindingsearch RNA polymerase II transcription factor bindingsearch ubiquitin protein ligase bindingsearch p53 bindingsearch dendritic spinesearch protein complexsearch beta-catenin destruction complexsearch cytosolsearch ribonucleoprotein complexsearch cytoplasmsearch nucleussearch plasma membranesearch centrosomesearch dendritic shaftsearch perinuclear region of cytoplasmsearch membrane-bounded organellesearch cell bodysearch neuronal cell bodysearch growth conesearch membranesearch membrane raftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch