4iq6 Summary


Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch tau protein bindingsearch protein serine/threonine kinase activitysearch beta-catenin bindingsearch tau-protein kinase activitysearch kinase activitysearch protein kinase A catalytic subunit bindingsearch nucleotide bindingsearch NF-kappaB bindingsearch protein kinase bindingsearch transferase activitysearch integrin bindingsearch ionotropic glutamate receptor bindingsearch ubiquitin protein ligase bindingsearch RNA polymerase II transcription factor bindingsearch p53 bindingsearch protein phosphorylationsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch circadian rhythmsearch Wnt signaling pathwaysearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch negative regulation of dendrite morphogenesissearch regulation of microtubule-based processsearch epidermal growth factor receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch phosphorylationsearch innate immune responsesearch cell migrationsearch fat cell differentiationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch neurotrophin TRK receptor signaling pathwaysearch response to lithium ionsearch myotube differentiationsearch negative regulation of MAP kinase activitysearch hypermethylation of CpG islandsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to interleukin-3search re-entry into mitotic cell cyclesearch establishment or maintenance of cell polaritysearch multicellular organismal developmentsearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch ER overload responsesearch positive regulation of protein complex assemblysearch fibroblast growth factor receptor signaling pathwaysearch negative regulation of apoptotic processsearch myoblast fusionsearch cell differentiationsearch negative regulation of signal transductionsearch negative regulation of protein bindingsearch protein export from nucleussearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch positive regulation of apoptotic processsearch positive regulation of protein bindingsearch rhythmic processsearch regulation of gene expression by genetic imprintingsearch protein localization to microtubulesearch superior temporal gyrus developmentsearch organ morphogenesissearch regulation of neuronal synaptic plasticitysearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch carbohydrate metabolic processsearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch response to drugsearch Fc-epsilon receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch glycogen metabolic processsearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein catabolic processsearch positive regulation of stem cell differentiationsearch axonogenesissearch establishment of cell polaritysearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch axon guidancesearch nervous system developmentsearch cellular response to mechanical stimulussearch negative regulation of cardiac muscle hypertrophysearch negative regulation of glycogen biosynthetic processsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch cytoplasmsearch cytosolsearch beta-catenin destruction complexsearch plasma membranesearch perinuclear region of cytoplasmsearch membranesearch protein complexsearch nucleussearch dendritic shaftsearch dendritic spinesearch membrane-bounded organellesearch ribonucleoprotein complexsearch growth conesearch centrosomesearch neuronal cell bodysearch membrane raftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch