4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein serine/threonine kinase activitysearch ATP bindingsearch tau protein bindingsearch beta-catenin bindingsearch protein bindingsearch tau-protein kinase activitysearch nucleotide bindingsearch kinase activitysearch NF-kappaB bindingsearch protein kinase A catalytic subunit bindingsearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein kinase bindingsearch integrin bindingsearch ubiquitin protein ligase bindingsearch p53 bindingsearch RNA polymerase II transcription factor bindingsearch ionotropic glutamate receptor bindingsearch protein phosphorylationsearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch peptidyl-serine phosphorylationsearch myotube differentiationsearch fat cell differentiationsearch negative regulation of neuron projection developmentsearch myoblast fusionsearch axonogenesissearch ER overload responsesearch phosphorylationsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch establishment or maintenance of cell polaritysearch circadian rhythmsearch innate immune responsesearch negative regulation of apoptotic processsearch negative regulation of neuron maturationsearch regulation of cellular response to heatsearch Wnt signaling pathwaysearch regulation of neuron projection developmentsearch positive regulation of stem cell differentiationsearch positive regulation of protein bindingsearch positive regulation of protein complex assemblysearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch cellular response to interleukin-3search establishment of cell polaritysearch negative regulation of protein bindingsearch regulation of microtubule-based processsearch rhythmic processsearch cellular response to heatsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of axon extensionsearch superior temporal gyrus developmentsearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch carbohydrate metabolic processsearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch positive regulation of canonical Wnt signaling pathwaysearch axon guidancesearch response to drugsearch hypermethylation of CpG islandsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch epidermal growth factor receptor signaling pathwaysearch glycogen metabolic processsearch Fc-epsilon receptor signaling pathwaysearch nervous system developmentsearch negative regulation of MAP kinase activitysearch response to lithium ionsearch cellular response to mechanical stimulussearch negative regulation of cardiac muscle hypertrophysearch protein export from nucleussearch multicellular organismal developmentsearch negative regulation of signal transductionsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch organ morphogenesissearch phosphatidylinositol-mediated signalingsearch cell differentiationsearch re-entry into mitotic cell cyclesearch regulation of neuronal synaptic plasticitysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of peptidyl-serine phosphorylationsearch protein localization to microtubulesearch negative regulation of glycogen biosynthetic processsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of gene expression by genetic imprintingsearch cell migrationsearch positive regulation of apoptotic processsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of protein catabolic processsearch negative regulation of dendrite morphogenesissearch beta-catenin destruction complexsearch cytosolsearch cytoplasmsearch plasma membranesearch centrosomesearch protein complexsearch nucleussearch membrane raftsearch growth conesearch dendritic shaftsearch membrane-bounded organellesearch perinuclear region of cytoplasmsearch membranesearch ribonucleoprotein complexsearch cell bodysearch neuronal cell bodysearch dendritic spinesearch nucleoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch