4iq6 Summary


Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P49841) plasma membranesearch nucleussearch dendritic spinesearch centrosomesearch membrane raftsearch beta-catenin destruction complexsearch cytoplasmsearch cytosolsearch membranesearch dendritic shaftsearch membrane-bounded organellesearch cell bodysearch ribonucleoprotein complexsearch growth conesearch nucleoplasmsearch neuronal cell bodysearch perinuclear region of cytoplasmsearch protein complexsearch protein bindingsearch transferase activitysearch NF-kappaB bindingsearch kinase activitysearch protein kinase bindingsearch protein serine/threonine kinase activitysearch tau-protein kinase activitysearch beta-catenin bindingsearch ionotropic glutamate receptor bindingsearch protein kinase A catalytic subunit bindingsearch integrin bindingsearch protein kinase activitysearch tau protein bindingsearch ATP bindingsearch p53 bindingsearch RNA polymerase II transcription factor bindingsearch nucleotide bindingsearch ubiquitin protein ligase bindingsearch transferase activity, transferring phosphorus-containing groupssearch negative regulation of MAP kinase activitysearch negative regulation of dendrite morphogenesissearch protein phosphorylationsearch negative regulation of protein bindingsearch peptidyl-serine phosphorylationsearch nervous system developmentsearch positive regulation of peptidyl-serine phosphorylationsearch ER overload responsesearch epidermal growth factor receptor signaling pathwaysearch negative regulation of apoptotic processsearch multicellular organismal developmentsearch Wnt signaling pathwaysearch glycogen metabolic processsearch innate immune responsesearch regulation of microtubule-based processsearch protein export from nucleussearch Fc-epsilon receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of neuron projection developmentsearch fat cell differentiationsearch canonical Wnt signaling pathwaysearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch fibroblast growth factor receptor signaling pathwaysearch circadian rhythmsearch positive regulation of protein complex assemblysearch cellular response to interleukin-3search axonogenesissearch regulation of gene expression by genetic imprintingsearch response to drugsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of stem cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch phosphorylationsearch positive regulation of apoptotic processsearch myotube differentiationsearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch regulation of neuronal synaptic plasticitysearch negative regulation of glycogen biosynthetic processsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch cellular response to mechanical stimulussearch negative regulation of cardiac muscle hypertrophysearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch superior temporal gyrus developmentsearch establishment of cell polaritysearch re-entry into mitotic cell cyclesearch rhythmic processsearch protein localization to microtubulesearch positive regulation of protein bindingsearch cell migrationsearch positive regulation of protein catabolic processsearch positive regulation of peptidyl-threonine phosphorylationsearch response to lithium ionsearch negative regulation of signal transductionsearch negative regulation of neuron maturationsearch positive regulation of transcription from RNA polymerase II promotersearch hypermethylation of CpG islandsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch carbohydrate metabolic processsearch axon guidancesearch establishment or maintenance of cell polaritysearch cell differentiationsearch organ morphogenesissearch negative regulation of protein complex assemblysearch myoblast fusionsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch