4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein bindingsearch tau-protein kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch tau protein bindingsearch protein kinase A catalytic subunit bindingsearch RNA polymerase II transcription factor bindingsearch nucleotide bindingsearch ionotropic glutamate receptor bindingsearch beta-catenin bindingsearch NF-kappaB bindingsearch p53 bindingsearch protein kinase bindingsearch identical protein bindingsearch transferase activitysearch ubiquitin protein ligase bindingsearch integrin bindingsearch protein localization to microtubulesearch myoblast fusionsearch negative regulation of transcription, DNA-dependentsearch canonical Wnt receptor signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch axonogenesissearch protein phosphorylationsearch organ morphogenesissearch positive regulation of cell-matrix adhesionsearch Fc-epsilon receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch phosphorylationsearch positive regulation of Rac GTPase activitysearch canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic processsearch glycogen metabolic processsearch myotube differentiationsearch negative regulation of dendrite morphogenesissearch positive regulation of stem cell differentiationsearch positive regulation of peptidyl-serine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch epithelial to mesenchymal transitionsearch peptidyl-serine phosphorylationsearch nervous system developmentsearch cell migrationsearch negative regulation of type B pancreatic cell developmentsearch negative regulation of signal transductionsearch ER overload responsesearch regulation of microtubule-based processsearch establishment of cell polaritysearch response to stresssearch innate immune responsesearch circadian rhythmsearch negative regulation of MAP kinase activitysearch positive regulation of protein catabolic processsearch carbohydrate metabolic processsearch multicellular organismal developmentsearch response to drugsearch negative regulation of apoptotic processsearch negative regulation of glycogen (starch) synthase activitysearch regulation of neuronal synaptic plasticitysearch negative regulation of protein complex assemblysearch protein export from nucleussearch Wnt receptor signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch epidermal growth factor receptor signaling pathwaysearch positive regulation of protein complex assemblysearch hippocampus developmentsearch hypermethylation of CpG islandsearch establishment or maintenance of cell polaritysearch fat cell differentiationsearch negative regulation of canonical Wnt receptor signaling pathwaysearch positive regulation of protein bindingsearch re-entry into mitotic cell cyclesearch regulation of gene expression by genetic imprintingsearch response to lithium ionsearch superior temporal gyrus developmentsearch cell differentiationsearch intracellular signal transductionsearch negative regulation of protein bindingsearch axon guidancesearch negative regulation of NFAT protein import into nucleussearch positive regulation of protein export from nucleussearch cytosolsearch protein complexsearch beta-catenin destruction complexsearch nucleussearch cytoplasmsearch dendritic spinesearch membrane-bounded organellesearch plasma membranesearch dendritic shaftsearch ribonucleoprotein complexsearch membranesearch neuronal cell bodysearch nucleolussearch perinuclear region of cytoplasmsearch membrane raftsearch centrosomesearch growth conesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch