4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) protein kinase activitysearch ATP bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch beta-catenin bindingsearch tau protein bindingsearch NF-kappaB bindingsearch protein kinase A catalytic subunit bindingsearch tau-protein kinase activitysearch protein kinase bindingsearch nucleotide bindingsearch transferase activitysearch p53 bindingsearch ionotropic glutamate receptor bindingsearch ubiquitin protein ligase bindingsearch RNA polymerase II transcription factor bindingsearch transferase activity, transferring phosphorus-containing groupssearch integrin bindingsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch myotube differentiationsearch regulation of neuronal synaptic plasticitysearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch glycogen metabolic processsearch negative regulation of neuron maturationsearch positive regulation of axon extensionsearch organ morphogenesissearch peptidyl-serine phosphorylationsearch ER overload responsesearch positive regulation of apoptotic processsearch positive regulation of GTPase activitysearch protein autophosphorylationsearch positive regulation of peptidyl-threonine phosphorylationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch negative regulation of neuron projection developmentsearch response to drugsearch positive regulation of peptidyl-serine phosphorylationsearch protein phosphorylationsearch negative regulation of protein bindingsearch positive regulation of stem cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch nervous system developmentsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of dendrite morphogenesissearch negative regulation of apoptotic processsearch positive regulation of protein complex assemblysearch innate immune responsesearch carbohydrate metabolic processsearch regulation of cellular response to heatsearch cellular response to interleukin-3search multicellular organismal developmentsearch negative regulation of NFAT protein import into nucleussearch negative regulation of cardiac muscle hypertrophysearch cellular response to mechanical stimulussearch cellular response to heatsearch positive regulation of protein bindingsearch positive regulation of canonical Wnt signaling pathwaysearch epidermal growth factor receptor signaling pathwaysearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch axon guidancesearch phosphorylationsearch axonogenesissearch negative regulation of signal transductionsearch superior temporal gyrus developmentsearch Fc-epsilon receptor signaling pathwaysearch Wnt signaling pathwaysearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch fibroblast growth factor receptor signaling pathwaysearch myoblast fusionsearch hypermethylation of CpG islandsearch fat cell differentiationsearch cell differentiationsearch establishment of cell polaritysearch re-entry into mitotic cell cyclesearch regulation of gene expression by genetic imprintingsearch positive regulation of protein catabolic processsearch phosphatidylinositol-mediated signalingsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch cell migrationsearch establishment or maintenance of cell polaritysearch response to lithium ionsearch negative regulation of MAP kinase activitysearch rhythmic processsearch regulation of microtubule-based processsearch negative regulation of glycogen biosynthetic processsearch circadian rhythmsearch protein export from nucleussearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch regulation of neuron projection developmentsearch neurotrophin TRK receptor signaling pathwaysearch protein localization to microtubulesearch cytosolsearch plasma membranesearch beta-catenin destruction complexsearch cytoplasmsearch centrosomesearch nucleussearch perinuclear region of cytoplasmsearch growth conesearch neuronal cell bodysearch cell bodysearch membranesearch membrane raftsearch dendritic shaftsearch dendritic spinesearch nucleoplasmsearch membrane-bounded organellesearch ribonucleoprotein complexsearch protein complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch