4iq6 Summary

pdbe.org/4iq6
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Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

The structure was published by Tong, Y., Stewart, K.D., Florjancic, A.S., et al., Johnson, E.F., Shoemaker, A.R., and Penning, T.D., in 2013 in a paper entitled "Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.12 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 426 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Sequence family (Pfam)
A, B (P49841) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P49841) ATP bindingsearch protein bindingsearch RNA polymerase II transcription factor bindingsearch kinase activitysearch ubiquitin protein ligase bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch integrin bindingsearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch tau-protein kinase activitysearch beta-catenin bindingsearch tau protein bindingsearch NF-kappaB bindingsearch protein kinase bindingsearch transferase activitysearch protein kinase A catalytic subunit bindingsearch ionotropic glutamate receptor bindingsearch p53 bindingsearch protein complexsearch membrane raftsearch cytosolsearch beta-catenin destruction complexsearch membranesearch plasma membranesearch dendritic shaftsearch nucleussearch cytoplasmsearch perinuclear region of cytoplasmsearch centrosomesearch ribonucleoprotein complexsearch dendritic spinesearch growth conesearch cell bodysearch neuronal cell bodysearch membrane-bounded organellesearch negative regulation of signal transductionsearch axon guidancesearch phosphorylationsearch negative regulation of dendrite morphogenesissearch cell migrationsearch negative regulation of canonical Wnt signaling pathwaysearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of MAP kinase activitysearch negative regulation of neuron projection developmentsearch circadian rhythmsearch cellular response to mechanical stimulussearch positive regulation of protein catabolic processsearch fat cell differentiationsearch Wnt signaling pathwaysearch glycogen metabolic processsearch positive regulation of protein bindingsearch protein phosphorylationsearch negative regulation of protein complex assemblysearch canonical Wnt signaling pathwaysearch response to drugsearch peptidyl-serine phosphorylationsearch innate immune responsesearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch regulation of gene expression by genetic imprintingsearch positive regulation of apoptotic processsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch protein localization to microtubulesearch ER overload responsesearch epidermal growth factor receptor signaling pathwaysearch multicellular organismal developmentsearch negative regulation of protein bindingsearch myoblast fusionsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch hypermethylation of CpG islandsearch cell differentiationsearch regulation of neuronal synaptic plasticitysearch positive regulation of transcription from RNA polymerase II promotersearch neurotrophin TRK receptor signaling pathwaysearch myotube differentiationsearch rhythmic processsearch establishment of cell polaritysearch re-entry into mitotic cell cyclesearch nervous system developmentsearch negative regulation of apoptotic processsearch positive regulation of protein complex assemblysearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch cellular response to interleukin-3search fibroblast growth factor receptor signaling pathwaysearch regulation of microtubule-based processsearch protein export from nucleussearch carbohydrate metabolic processsearch Fc-epsilon receptor signaling pathwaysearch phosphatidylinositol-mediated signalingsearch negative regulation of NFAT protein import into nucleussearch positive regulation of Rac GTPase activitysearch positive regulation of stem cell differentiationsearch negative regulation of neuron maturationsearch superior temporal gyrus developmentsearch positive regulation of cell-matrix adhesionsearch hippocampus developmentsearch response to lithium ionsearch intracellular signal transductionsearch positive regulation of protein export from nucleussearch positive regulation of peptidyl-threonine phosphorylationsearch establishment or maintenance of cell polaritysearch negative regulation of cardiac muscle hypertrophysearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of glycogen biosynthetic processsearch organ morphogenesissearch axonogenesissearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch