› 4ipa

X-ray diffraction
2.3Å resolution

Structure of a thermophilic Arx1

Released:
DOI: 10.2210/pdb4ipa/pdb
PDB entry 4ipa coloured by chain, front view.
PDB entry 4ipa coloured by chain, side view.
PDB entry 4ipa coloured by chain, top view.
Source organism: Chaetomium thermophilum var. thermophilum DSM 1495
Primary publication:
Consistent mutational paths predict eukaryotic thermostability.
van Noort V, Bradatsch B, Arumugam M, Amlacher S, Bange G, Creevey C, Falk S, Mende DR, Sinning I, Hurt E, Bork P
BMC Evol Biol 13 7 (2013)
PMID: 23305080

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123992 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase M24 domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 423 amino acids
Theoretical weight: 46.69 KDa
Source organism: Chaetomium thermophilum var. thermophilum DSM 1495
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G0S4S7 (Residues: 1-415; Coverage: 100%)
Gene name: CTHT_0023380
Sequence domains: Metallopeptidase family M24
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 191.998Å b: 193.316Å c: 70.913Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The survival mechanisms of thermophiles at high temperatures: an angle of omics.
Wang et al. (2015)
1 more

1 mention without citation

Consistent mutational paths predict eukaryotic thermostability.
van Noort et al. (2013)