4imx Summary


Structure of bovine endothelial nitric oxide synthase heme domain in complex with 3,5-bis(2-(6-amino-4-methylpyridin-2-yl)ethyl)benzonitrile

The structure was published by Huang, H., Li, H., Martasek, P., Roman, L.J., Poulos, T.L., and Silverman, R.B., in 2013 in a paper entitled "Structure-guided design of selective inhibitors of neuronal nitric oxide synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of subunit A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A subunit A P29473 (40-482) (NOS3_BOVIN)search Bos taurussearch < 90% 442 91%
B subunit A P29473 (40-482) (NOS3_BOVIN)search Bos taurussearch < 90% 442 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29473 (40 - 482) subunit A Bos taurus

Chain Sequence family (Pfam)
A, B Nitric oxide synthase, oxygenase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P29473) oxidation-reduction processsearch nitric oxide biosynthetic processsearch nitric-oxide synthase activitysearch

Chain InterPro annotation
A, B Nitric oxide synthase, N-terminalsearch