4ilx Summary


Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor

The structure was published by Biswas, S., Carta, F., Scozzafava, A., McKenna, R., and Supuran, C.T., in 2013 in a paper entitled "Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 257 residues which is 99% of the natural sequence. Out of 257 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (4-260) (CAH2_HUMAN)search Homo sapienssearch 98% 257 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (4 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of anion transportsearch response to pHsearch secretionsearch regulation of intracellular pHsearch response to organic substancesearch kidney developmentsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to estrogensearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch morphogenesis of an epitheliumsearch response to zinc ionsearch plasma membranesearch cytosolsearch microvillussearch membranesearch apical part of cellsearch cytoplasmsearch extracellular spacesearch basolateral plasma membranesearch myelin sheathsearch extracellular vesicular exosomesearch axonsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch