4iiq Summary

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Crystal structure of a human MAIT TCR in complex with bovine MR1

The structure was published by Lopez-Sagaseta, J., Dulberger, C.L., Crooks, J.E., et al., Van Rhijn, I., Saghatelian, A., and Adams, E.J., in 2013 in a paper entitled "The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.86 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Human Mucosal Associated Invariant T cell receptor alpha chain, Human Mucosal Associated Invariant T cell receptor beta chain, and Beta-2-microglobulin, MHC class I-related protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Human Mucosal Associated Invariant T cell receptor alpha chain Q6P4G7 (6-213) (Q6P4G7_HUMAN)search Homo sapienssearch < 90% 205 96%
B Human Mucosal Associated Invariant T cell receptor beta chain P01850 (1-130) (TRBC1_HUMAN)search Homo sapienssearch < 90% 253 96%
C Beta-2-microglobulin, MHC class I-related protein C1ITJ8 (19-295) (C1ITJ8_BOVIN)search ,
P01888 (21-118) (B2MG_BOVIN)search
Bos taurussearch ,
Bos taurussearch
< 90% ,
100%
392 91%


Chain Sequence family (Pfam)
A Immunoglobulin V-set domainsearch, Domain of unknown function (DUF1968)search
B Immunoglobulin C1-set domainsearch
C (P01888) PF07654: Immunoglobulin C1-set domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
C (P01888C1ITJ8) antigen processing and presentation of peptide antigen via MHC class Isearch protein refoldingsearch antigen processing and presentationsearch immune responsesearch positive regulation of T cell mediated cytotoxicitysearch antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentsearch response to molecule of bacterial originsearch T cell differentiation in thymussearch membranesearch MHC class I protein complexsearch external side of plasma membranesearch extracellular regionsearch peptide antigen bindingsearch

Chain InterPro annotation
A Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
B Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C MHC class I alpha chain, alpha1 alpha2 domainssearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC class I-like antigen recognitionsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch