4ih6 Summary

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Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds

The structure was published by Talamas, F.X., Ao-Ieong, G., Brameld, K.A., et al., Schoenfeld, R.C., Wang, B., and Wong, A., in 2013 in a paper entitled "De novo fragment design: a medicinal chemistry approach to fragment-based lead generation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RNA-directed RNA polymerase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RNA-directed RNA polymerase P26663 (2421-2989) (POLG_HCVBK)search Hepatitis C virus (isolate BK)search < 90% 570 97%
B RNA-directed RNA polymerase P26663 (2421-2989) (POLG_HCVBK)search Hepatitis C virus (isolate BK)search < 90% 570 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26663 (2421 - 2989) RNA-directed RNA polymerase Hepatitis C virus (isolate BK)

Chain Sequence family (Pfam)
A, B Viral RNA dependent RNA polymerasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P26663) RNA bindingsearch RNA-directed RNA polymerase activitysearch viral RNA genome replicationsearch

Chain InterPro annotation
A, B RNA dependent RNA polymerase, hepatitis C virussearch RNA-directed RNA polymerase, catalytic domainsearch