Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds
The structure was published by Talamas, F.X., Ao-Ieong, G., Brameld, K.A., et al., Schoenfeld, R.C., Wang, B., and Wong, A., in 2013 in a paper entitled "De novo fragment design: a medicinal chemistry approach to fragment-based lead generation." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of RNA-directed RNA polymerase.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: