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Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds

X-ray diffraction
2.2Å resolution
PDB entry 4ih6 coloured by chain, front view.
PDB entry 4ih6 coloured by chain, side view.
PDB entry 4ih6 coloured by chain, top view.
Source organism: Hepatitis C virus (isolate BK)
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease/helicase NS3
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Multimeric state: monomeric
Accessible surface area: 22959.34 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150808
Assembly 2
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Assembly Name: Serine protease/helicase NS3
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Multimeric state: monomeric
Accessible surface area: 22879.41 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150808

Macromolecules

RNA-directed RNA polymerase
Chains: A, B
Length: 570 amino acids
Theoretical weight: 63.35 KDa
Source organism: Hepatitis C virus (isolate BK)
Expression system: Escherichia coli
UniProt:
  • Canonical: P26663 (Residues: 2421-2989; Coverage: 19%)
Pfam: Viral RNA dependent RNA polymerase
InterPro:
CATH: Alpha-Beta Plaits
RNA-directed RNA polymerase in PDB entry 4ih6, assembly 1, front view.
RNA-directed RNA polymerase in PDB entry 4ih6, assembly 1, side view.
RNA-directed RNA polymerase in PDB entry 4ih6, assembly 1, top view.
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