4ic7 Summary

pdbe.org/4ic7
spacer

Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment

The structure was published by Glatz, G., Gogl, G., Alexa, A., and Remenyi, A., in 2013 in a paper entitled "Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase 7 and Dual specificity mitogen-activated protein kinase kinase 5.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 7 Q13164 (1-431) (MK07_HUMAN)search Homo sapienssearch < 90% 442 80%
D Mitogen-activated protein kinase 7 Q13164 (1-431) (MK07_HUMAN)search Homo sapienssearch < 90% 442 80%
E Dual specificity mitogen-activated protein kinase kinase 5 Q13163 (16-130) (MP2K5_HUMAN)search Homo sapienssearch < 90% 126 97%
B Dual specificity mitogen-activated protein kinase kinase 5 Q13163 (16-130) (MP2K5_HUMAN)search Homo sapienssearch < 90% 126 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13164 (1 - 431) Mitogen-activated protein kinase 7 Homo sapiens
Q13163 (16 - 130) Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens

Chain Sequence family (Pfam)
A, D Protein kinase domainsearch
E, B PB1 domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, D (Q13164) protein phosphorylationsearch ATP bindingsearch protein serine/threonine kinase activitysearch MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, D Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
E, B Phox/Bem1psearch