› 4ian

X-ray diffraction
2.44Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PRP4 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 358 amino acids
Theoretical weight: 41.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13523 (Residues: 657-1007; Coverage: 35%)
Gene names: KIAA0536, PRP4, PRP4B, PRP4H, PRP4K, PRPF4K
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 73.266Å b: 75.286Å c: 148.003Å
α: 90° β: 97.21° γ: 90°
R-values:
R R work R free
0.228 0.228 0.288
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Pharmacology of Modulators of Alternative Splicing.
Bates et al. (2017)
3 more

1 mention without citation

Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
Gao et al. (2013)