4i4h Summary


Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir

The structure was published by Sevrioukova, I.F. and Poulos, T.L., in 2013 in a paper entitled "Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cytochrome P450 3A4. This molecule has the UniProt identifier P08684 (CP3A4_HUMAN)search. The sample contained 487 residues which is 96% of the natural sequence. Out of 487 residues 457 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytochrome P450 3A4 P08684 (23-503) (CP3A4_HUMAN)search Homo sapienssearch 95% 487 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08684 (23 - 503) Cytochrome P450 3A4 Homo sapiens

Chain Sequence family (Pfam)
A (P08684) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P08684) steroid bindingsearch monooxygenase activitysearch oxidoreductase activitysearch oxygen bindingsearch heme bindingsearch caffeine oxidase activitysearch steroid hydroxylase activitysearch iron ion bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygensearch quinine 3-monooxygenase activitysearch vitamin D 24-hydroxylase activitysearch albendazole monooxygenase activitysearch vitamin D3 25-hydroxylase activitysearch enzyme bindingsearch taurochenodeoxycholate 6alpha-hydroxylase activitysearch testosterone 6-beta-hydroxylase activitysearch metal ion bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch monoterpenoid metabolic processsearch oxidation-reduction processsearch xenobiotic metabolic processsearch heterocycle metabolic processsearch oxidative demethylationsearch steroid catabolic processsearch small molecule metabolic processsearch vitamin D metabolic processsearch lipid metabolic processsearch drug catabolic processsearch alkaloid catabolic processsearch exogenous drug catabolic processsearch drug metabolic processsearch steroid metabolic processsearch calcitriol biosynthetic process from calciolsearch androgen metabolic processsearch intracellular membrane-bounded organellesearch integral component of membranesearch membranesearch endoplasmic reticulum membranesearch endoplasmic reticulumsearch cytoplasmsearch

Chain InterPro annotation
A Cytochrome P450search Cytochrome P450, E-class, group IIsearch Cytochrome P450, E-class, CYP3Asearch Cytochrome P450, conserved sitesearch