4i4h Summary

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Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir

The structure was published by Sevrioukova, I.F. and Poulos, T.L., in 2013 in a paper entitled "Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cytochrome P450 3A4. This molecule has the UniProt identifier P08684 (CP3A4_HUMAN)search. The sample contained 487 residues which is 96% of the natural sequence. Out of 487 residues 457 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytochrome P450 3A4 P08684 (23-503) (CP3A4_HUMAN)search Homo sapienssearch 95% 487 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08684 (23 - 503) Cytochrome P450 3A4 Homo sapiens

Chain Sequence family (Pfam)
A (P08684) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P08684) monooxygenase activitysearch steroid bindingsearch iron ion bindingsearch steroid hydroxylase activitysearch oxidoreductase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygensearch oxygen bindingsearch enzyme bindingsearch heme bindingsearch vitamin D3 25-hydroxylase activitysearch taurochenodeoxycholate 6alpha-hydroxylase activitysearch caffeine oxidase activitysearch metal ion bindingsearch albendazole monooxygenase activitysearch quinine 3-monooxygenase activitysearch testosterone 6-beta-hydroxylase activitysearch vitamin D 24-hydroxylase activitysearch cytoplasmsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch membranesearch integral component of membranesearch organelle membranesearch intracellular membrane-bounded organellesearch lipid metabolic processsearch steroid catabolic processsearch xenobiotic metabolic processsearch steroid metabolic processsearch androgen metabolic processsearch alkaloid catabolic processsearch monoterpenoid metabolic processsearch drug metabolic processsearch calcitriol biosynthetic process from calciolsearch vitamin D metabolic processsearch drug catabolic processsearch exogenous drug catabolic processsearch small molecule metabolic processsearch heterocycle metabolic processsearch oxidation-reduction processsearch oxidative demethylationsearch

Chain InterPro annotation
A Cytochrome P450search Cytochrome P450, E-class, group IIsearch Cytochrome P450, E-class, CYP3Asearch Cytochrome P450, conserved sitesearch