Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir
The structure was published by Sevrioukova, I.F. and Poulos, T.L., in 2013 in a paper entitled "Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Cytochrome P450 3A4. This molecule has the UniProt identifier P08684 (CP3A4_HUMAN). The sample contained 487 residues which is 96% of the natural sequence. Out of 487 residues 457 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: