4i4h Summary

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Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir

The structure was published by Sevrioukova, I.F. and Poulos, T.L., in 2013 in a paper entitled "Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cytochrome P450 3A4. This molecule has the UniProt identifier P08684 (CP3A4_HUMAN)search. The sample contained 487 residues which is 96% of the natural sequence. Out of 487 residues 457 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytochrome P450 3A4 P08684 (23-503) (CP3A4_HUMAN)search Homo sapienssearch 95% 487 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08684 (23 - 503) Cytochrome P450 3A4 Homo sapiens

Chain Sequence family (Pfam)
A (P08684) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P08684) oxidoreductase activitysearch iron ion bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygensearch heme bindingsearch monooxygenase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch enzyme bindingsearch vitamin D3 25-hydroxylase activitysearch steroid bindingsearch quinine 3-monooxygenase activitysearch electron carrier activitysearch taurochenodeoxycholate 6alpha-hydroxylase activitysearch caffeine oxidase activitysearch oxygen bindingsearch albendazole monooxygenase activitysearch vitamin D 24-hydroxylase activitysearch steroid hydroxylase activitysearch metal ion bindingsearch testosterone 6-beta-hydroxylase activitysearch oxidation-reduction processsearch xenobiotic metabolic processsearch lipid metabolic processsearch androgen metabolic processsearch steroid metabolic processsearch heterocycle metabolic processsearch monoterpenoid metabolic processsearch oxidative demethylationsearch steroid catabolic processsearch drug metabolic processsearch drug catabolic processsearch calcitriol biosynthetic process from calciolsearch vitamin D metabolic processsearch exogenous drug catabolic processsearch small molecule metabolic processsearch alkaloid catabolic processsearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch organelle membranesearch integral to membranesearch membranesearch cell surfacesearch endoplasmic reticulumsearch cytoplasmsearch

Chain InterPro annotation
A Cytochrome P450search Cytochrome P450, E-class, group IIsearch Cytochrome P450, E-class, CYP3Asearch Cytochrome P450, conserved sitesearch