4i4g Summary


Crystal structure of CYP3A4 ligated to oxazole-substituted desoxyritonavir

The structure was published by Sevrioukova, I.F. and Poulos, T.L., in 2013 in a paper entitled "Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.718 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cytochrome P450 3A4. This molecule has the UniProt identifier P08684 (CP3A4_HUMAN)search. The sample contained 487 residues which is 96% of the natural sequence. Out of 487 residues 459 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytochrome P450 3A4 P08684 (23-503) (CP3A4_HUMAN)search Homo sapienssearch 95% 487 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08684 (23 - 503) Cytochrome P450 3A4 Homo sapiens

Chain Sequence family (Pfam)
A (P08684) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P08684) monooxygenase activitysearch iron ion bindingsearch metal ion bindingsearch steroid bindingsearch vitamin D3 25-hydroxylase activitysearch caffeine oxidase activitysearch oxidoreductase activitysearch enzyme bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygensearch taurochenodeoxycholate 6alpha-hydroxylase activitysearch oxygen bindingsearch albendazole monooxygenase activitysearch quinine 3-monooxygenase activitysearch vitamin D 24-hydroxylase activitysearch testosterone 6-beta-hydroxylase activitysearch steroid hydroxylase activitysearch heme bindingsearch androgen metabolic processsearch drug catabolic processsearch alkaloid catabolic processsearch drug metabolic processsearch xenobiotic metabolic processsearch oxidative demethylationsearch small molecule metabolic processsearch lipid metabolic processsearch monoterpenoid metabolic processsearch oxidation-reduction processsearch steroid metabolic processsearch heterocycle metabolic processsearch exogenous drug catabolic processsearch calcitriol biosynthetic process from calciolsearch vitamin D metabolic processsearch steroid catabolic processsearch membranesearch intracellular membrane-bounded organellesearch organelle membranesearch endoplasmic reticulum membranesearch cytoplasmsearch integral component of membranesearch endoplasmic reticulumsearch

Chain InterPro annotation
A Cytochrome P450search Cytochrome P450, E-class, group IIsearch Cytochrome P450, E-class, CYP3Asearch Cytochrome P450, conserved sitesearch