spacer Crystal structure of CYP3A4 ligated to oxazole-substituted desoxyritonavir
UniProt
Accession P08684search
Name CP3A4_HUMAN
Keywords Iron, NADP, Membrane, Transmembrane, 3D-structure, Ubl conjugation, Microsome, Complete proteome, Endoplasmic reticulum, Heme, Direct protein sequencing, Transmembrane helix, Metal-binding, Polymorphism, Reference proteome, Oxidoreductase, Monooxygenase
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Polymers A
 
Enzyme nomenclature
EC number 1.14.13.67 ExPASy BRENDA search
Polymers A
Name quinine 3-monooxygenase
EC number 1.14.13.97 ExPASy BRENDA search
Polymers A
Name taurochenodeoxycholate 6alpha-hydroxylase
Comment A heme-thiolate protein (P-450). Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid.
EC number 1.14.13.157 ExPASy BRENDA search
Polymers A
Name 1,8-cineole 2-exo-monooxygenase
Comment A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics. Cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase).
EC number 1.14.13.32 ExPASy BRENDA search
Polymers A
Name albendazole monooxygenase
Comment A flavoprotein (FAD).
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