4hyf Summary


Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor

The structure was published by Voronkov, A., Holsworth, D.D., Waaler, J., et al., Hopf, C., Morth, J.P., and Krauss, S., in 2013 in a paper entitled "Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tankyrase-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tankyrase-2 Q9H2K2 (946-1162) (TNKS2_HUMAN)search Homo sapienssearch < 90% 240 94%
B Tankyrase-2 Q9H2K2 (946-1162) (TNKS2_HUMAN)search Homo sapienssearch < 90% 240 94%
C Tankyrase-2 Q9H2K2 (946-1162) (TNKS2_HUMAN)search Homo sapienssearch < 90% 240 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9H2K2 (946 - 1162) Tankyrase-2 Homo sapiens

Chain Sequence family (Pfam)
A, B, C Poly(ADP-ribose) polymerase catalytic domainsearch

Chain ID Molecular function (GO)
A, B, C (Q9H2K2) NAD+ ADP-ribosyltransferase activitysearch

Chain InterPro annotation
A, B, C Poly(ADP-ribose) polymerase, catalytic domainsearch