› 4hwu

X-ray diffraction
2.9Å resolution

Crystal structure of the Ig-C2 type 1 domain from mouse Fibroblast growth factor receptor 2 (FGFR2) [NYSGRC-005912]

Released:
DOI: 10.2210/pdb4hwu/pdb
PDB entry 4hwu coloured by chain, front view.
PDB entry 4hwu coloured by chain, side view.
PDB entry 4hwu coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Kumar PR, Ahmed M, Banu R, Bhosle R, Calarese D, Celikigil A, Chamala S, Chan MK, Chowdhury S, Fiser A, Garforth S, Glenn AS, Hillerich B, Khafizov K, Love J, Patel H, Rubinstein R, Seidel R, Stead M, Toro R, Nathenson SG, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149432 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.38 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P21803 (Residues: 45-127; Coverage: 10%)
Gene names: Bek, Ect1, Fgfr2
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3121
Unit cell:
a: 53.818Å b: 53.818Å c: 122.817Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.226 0.252
Expression system: Trichoplusia ni

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