4hu1 Summary


Crystal structure of human carbonic anhydrase isozyme XIII with the inhibitor.

The structure was published by Dudutiene, V., Zubriene, A., Smirnov, A., et al., Manakova, E., Grazulis, S., and Matulis, D., in 2013 in a paper entitled "4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carbonic anhydrase 13.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Carbonic anhydrase 13 Q8N1Q1 (1-262) (CAH13_HUMAN)search Homo sapienssearch 100% 263 98%
A Carbonic anhydrase 13 Q8N1Q1 (1-262) (CAH13_HUMAN)search Homo sapienssearch 100% 263 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8N1Q1 (1 - 262) Carbonic anhydrase 13 Homo sapiens

Chain Sequence family (Pfam)
B, A (Q8N1Q1) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
B, A (Q8N1Q1) metal ion bindingsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch cytosolsearch myelin sheathsearch bicarbonate transportsearch small molecule metabolic processsearch one-carbon metabolic processsearch

Chain InterPro annotation
B, A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, alpha-classsearch