› 4hqp

X-ray diffraction
3.51Å resolution

Alpha7 nicotinic receptor chimera and its complex with Alpha bungarotoxin

Released:
DOI: 10.2210/pdb4hqp/pdb
PDB entry 4hqp coloured by chain, front view.
PDB entry 4hqp coloured by chain, side view.
PDB entry 4hqp coloured by chain, top view.
Source organisms:
Entry authors: Li SX, Cheng K, Gomoto R, Bren N, Huang S, Sine S, Chen L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157654 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Acetylcholine-binding protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 202 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P58154 (Residues: 35-91, 92-224; Coverage: 89%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain
Alpha-bungarotoxin isoform V31 Chains: F, G, H, I, J
Molecule details ›
Chains: F, G, H, I, J
Length: 73 amino acids
Theoretical weight: 7.98 KDa
Source organism: Bungarus multicinctus
UniProt:
  • Canonical: P60616 (Residues: 22-94; Coverage: 99%)
Structure domains: CD59

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1, APS BEAMLINE 23-ID-B, APS BEAMLINE 21-ID-D
Spacegroup: P6522
Unit cell:
a: 142.15Å b: 142.15Å c: 518.135Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.311 0.311 0.321
Expression system: Komagataella pastoris

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