› 4hpy

X-ray diffraction
1.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-124668 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 23.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6N089 (Residues: 20-247; Coverage: 50%)
Gene name: DKFZp686P15220
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 22.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N5F4 (Residues: 20-233; Coverage: 100%)
Gene name: IGL@
Sequence domains:
Structure domains: Immunoglobulins
Envelope glycoprotein gp160 Chain: P
Molecule details ›
Chain: P
Length: 19 amino acids
Theoretical weight: 2.35 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: G9HS63 (Residues: 166-184; Coverage: 2%)
Gene name: env

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 41.888Å b: 79.15Å c: 127.112Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.187
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

59 review citations

HIV-1 neutralizing antibodies: understanding nature's pathways.
Mascola et al. (2013)
58 more

8 mentions without citation

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.
Liao et al. (2013)
7 more