4hoe Summary


Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)

The structure was published by G-Dayanandan, N., Paulsen, J.L., Viswanathan, K., et al., Priestley, N.D., Wright, D.L., and Anderson, A.C., in 2014 in a paper entitled "Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.76 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Dihydrofolate reductase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dihydrofolate reductase P22906 (1-192) (DYR_CANAX)search Candida albicanssearch 98% 192 100%
B Dihydrofolate reductase P22906 (1-192) (DYR_CANAX)search Candida albicanssearch 98% 192 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22906 (1 - 192) Dihydrofolate reductase Candida albicans

Chain Sequence family (Pfam)
A, B (P22906) PF00186: Dihydrofolate reductasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P22906) dihydrofolate reductase activitysearch oxidoreductase activitysearch NADP bindingsearch glycine biosynthetic processsearch one-carbon metabolic processsearch nucleotide biosynthetic processsearch tetrahydrofolate biosynthetic processsearch oxidation-reduction processsearch

Chain InterPro annotation
A, B Dihydrofolate reductase domainsearch Dihydrofolate reductasesearch Dihydrofolate reductase conserved sitesearch Dihydrofolate reductase-like domainsearch