4hib Summary


Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH

The structure was published by Purohit, M.K., Poduch, E., Wei, L.W., et al., Kain, K.C., Pai, E.F., and Kotra, L.P., in 2012 in a paper entitled "Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Uridine 5'-monophosphate synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Uridine 5'-monophosphate synthase P11172 (190-480) (UMPS_HUMAN)search Homo sapienssearch < 90% 312 82%
B Uridine 5'-monophosphate synthase P11172 (190-480) (UMPS_HUMAN)search Homo sapienssearch < 90% 312 82%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11172 (190 - 480) Uridine 5'-monophosphate synthase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Aldolase class Isearch Orotidine 5'-phosphate decarboxylase / HUMPS familysearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P11172) 'de novo' pyrimidine nucleobase biosynthetic processsearch metabolic processsearch 'de novo' UMP biosynthetic processsearch orotidine-5'-phosphate decarboxylase activitysearch catalytic activitysearch

Chain InterPro annotation
A, B Orotidine 5'-phosphate decarboxylase domainsearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Orotidine 5'-phosphate decarboxylasesearch Orotidine 5'-phosphate decarboxylase, active sitesearch