4hhb Summary

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THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

The structure was published by Fermi, G., Perutz, M.F., Shaanan, B., and Fourme, R., in 1984 in a paper entitled "The crystal structure of human deoxyhaemoglobin at 1.74 A resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.74 Å and deposited in 1984.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch transportsearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch small molecule metabolic processsearch hemoglobin complexsearch blood microparticlesearch extracellular regionsearch membranesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch cytosolsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch
B, D (P68871) bicarbonate transportsearch small molecule metabolic processsearch renal absorptionsearch platelet aggregationsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch blood coagulationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch transportsearch response to hydrogen peroxidesearch regulation of blood pressuresearch oxidation-reduction processsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch heme bindingsearch iron ion bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch