4hhb Summary

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THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

The structure was published by Fermi, G., Perutz, M.F., Shaanan, B., and Fourme, R., in 1984 in a paper entitled "The crystal structure of human deoxyhaemoglobin at 1.74 A resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.74 Å and deposited in 1984.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) extracellular vesicular exosomesearch cytosolsearch hemoglobin complexsearch membranesearch extracellular regionsearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch protein bindingsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch small molecule metabolic processsearch oxygen transportsearch positive regulation of cell deathsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch transportsearch response to hydrogen peroxidesearch
B, D (P68871) extracellular vesicular exosomesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen transportsearch transportsearch renal absorptionsearch small molecule metabolic processsearch regulation of blood vessel sizesearch platelet aggregationsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch blood coagulationsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch