4hhb Summary

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THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

The structure was published by Fermi, G., Perutz, M.F., Shaanan, B., and Fourme, R., in 1984 in a paper entitled "The crystal structure of human deoxyhaemoglobin at 1.74 A resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.74 Å and deposited in 1984.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) protein bindingsearch heme bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen bindingsearch positive regulation of cell deathsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch blood microparticlesearch extracellular regionsearch membranesearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch small molecule metabolic processsearch platelet aggregationsearch oxidation-reduction processsearch renal absorptionsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxygen transportsearch blood coagulationsearch bicarbonate transportsearch nitric oxide transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch transportsearch regulation of blood pressuresearch extracellular vesicular exosomesearch cytosolsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch