4hhb Summary

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THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION

The structure was published by Fermi, G., Perutz, M.F., Shaanan, B., and Fourme, R., in 1984 in a paper entitled "The crystal structure of human deoxyhaemoglobin at 1.74 A resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.74 Å and deposited in 1984.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch transportsearch bicarbonate transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxygen transportsearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch
B, D (P68871) protein bindingsearch heme bindingsearch oxygen transporter activitysearch peroxidase activitysearch iron ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch metal ion bindingsearch extracellular regionsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch response to hydrogen peroxidesearch protein heterooligomerizationsearch regulation of blood vessel sizesearch transportsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch oxygen transportsearch bicarbonate transportsearch blood coagulationsearch regulation of blood pressuresearch renal absorptionsearch small molecule metabolic processsearch platelet aggregationsearch positive regulation of cell deathsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch