› 4hc1

X-ray diffraction
2.87Å resolution

Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3

Released:
DOI: 10.2210/pdb4hc1/pdb
PDB entry 4hc1 coloured by chain, front view.
PDB entry 4hc1 coloured by chain, side view.
PDB entry 4hc1 coloured by chain, top view.
Source organisms:
Entry authors: Springer T, Yu Y, Zhu J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212006 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Mucosal addressin cell adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 206 amino acids
Theoretical weight: 21.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13477 (Residues: 23-171, 180-224; Coverage: 53%)
Gene name: MADCAM1
Sequence domains: Adhesion molecule, immunoglobulin-like
Structure domains: Immunoglobulins
10G3 heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 220 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
10G3 light chain Chains: L, N
Molecule details ›
Chains: L, N
Length: 214 amino acids
Theoretical weight: 23.57 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 317.854Å b: 71.727Å c: 70.557Å
α: 90° β: 93.29° γ: 90°
R-values:
R R work R free
0.232 0.2 0.253
Expression systems:
  • Homo sapiens
  • Mus musculus

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