4h3b Summary

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Crystal Structure of JNK3 in Complex with SAB Peptide

The structure was published by Laughlin, J.D., Nwachukwu, J.C., Figuera-Losada, M., Cherry, L., Nettles, K.W., and Lograsso, P.V., in 2012 in a paper entitled "Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.08 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase 10 and SH3 domain-binding protein 5.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 10 P53779 (46-400) (MK10_HUMAN)search Homo sapienssearch 91% 356 98%
C Mitogen-activated protein kinase 10 P53779 (46-400) (MK10_HUMAN)search Homo sapienssearch 91% 356 98%
B SH3 domain-binding protein 5 O60239 (341-350) (3BP5_HUMAN)search Homo sapienssearch < 90% 10 100%
D SH3 domain-binding protein 5 O60239 (341-350) (3BP5_HUMAN)search Homo sapienssearch < 90% 10 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P53779 (46 - 400) Mitogen-activated protein kinase 10 Homo sapiens
O60239 (341 - 350) SH3 domain-binding protein 5 Homo sapiens

Chain Sequence family (Pfam)
A, C (P53779) PF00069: Protein kinase domainsearch
B, D

Chain ID Molecular function (GO) Biological process (GO)
A, C (P53779) protein serine/threonine kinase activitysearch ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch
B, D