4h1q Summary

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Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

A publication describing this structure is not available. The depositing authors are Stura, E.A.search; Vera, L.search; Cassar-Lajeunesse, E.search; Nuti, E.search; Catalani, M.P.search; Dive, V.search; Rossello, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Matrix metalloproteinase-9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Matrix metalloproteinase-9 P14780 (110-214) (MMP9_HUMAN)search ,
P14780 (391-444) (MMP9_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
160 100%
B Matrix metalloproteinase-9 P14780 (110-214) (MMP9_HUMAN)search ,
P14780 (391-444) (MMP9_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
160 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14780 (110 - 214) Matrix metalloproteinase-9 Homo sapiens

Chain Sequence family (Pfam)
A, B Matrixinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P14780) metallopeptidase activitysearch zinc ion bindingsearch metalloendopeptidase activitysearch proteolysissearch leukocyte migrationsearch collagen catabolic processsearch ossificationsearch extracellular matrixsearch

Chain InterPro annotation
A, B Peptidase M10, metallopeptidasesearch Peptidase, metallopeptidasesearch Peptidase M10Asearch Metallopeptidase, catalytic domainsearch Matrix metalloproteinase-9search