4gs0 Summary


Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide

The structure was published by Alicea-Velazquez, N.L., Jakoncic, J., and Boggon, T.J., in 2013 in a paper entitled "Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7961 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tyrosine-protein phosphatase non-receptor type 6 and Tyrosine-protein kinase JAK1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein phosphatase non-receptor type 6 P29350 (243-528) (PTN6_HUMAN)search Homo sapienssearch 100% 308 90%
B Tyrosine-protein phosphatase non-receptor type 6 P29350 (243-528) (PTN6_HUMAN)search Homo sapienssearch 100% 308 90%
C Tyrosine-protein kinase JAK1 Not available
Homo sapienssearch Not available 4 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29350 (243 - 528) Tyrosine-protein phosphatase non-receptor type 6 Homo sapiens

Chain Sequence family (Pfam)
A, B (P29350) PF00102: Protein-tyrosine phosphatasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P29350) dephosphorylationsearch protein dephosphorylationsearch protein tyrosine phosphatase activitysearch phosphatase activitysearch

Chain InterPro annotation
A, B Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch