› 4goe

X-ray diffraction
1.45Å resolution

Crystal structure of the SGTA homodimerization domain with a covalent modification of a single C38

Released:
DOI: 10.2210/pdb4goe/pdb
PDB entry 4goe coloured by chain, front view.
PDB entry 4goe coloured by chain, side view.
PDB entry 4goe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Chartron JW, VanderVelde DG, Clemons WM
Cell Rep 2 1620-32 (2012)
PMID: 23142665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129106 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 52 amino acids
Theoretical weight: 5.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43765 (Residues: 4-54; Coverage: 16%)
Gene names: SGT, SGT1, SGTA
Sequence domains: Homodimerisation domain of SGTA
Structure domains: Immunoglobulin FC, subunit C

Ligands and Environments

2 bound ligands:
Ligand BME 1 x BME
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Unit cell:
a: 29.726Å b: 44.132Å c: 63.975Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.203
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion.
Chio et al. (2017)
10 more

1 mention without citation

Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Chartron et al. (2012)