4gg6 Summary

pdbe.org/4gg6
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Protein complex

The structure was published by Broughton, S.E., Petersen, J., Theodossis, A., et al., Koning, F., Reid, H.H., and Rossjohn, J., in 2012 in a paper entitled "Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This entry contains 13 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DQ alpha 1 chain P01909 (24-77) (DQA1_HUMAN)search ,
P01909 (78-206) (DQA1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
192 94%
C HLA class II histocompatibility antigen, DQ alpha 1 chain P01909 (24-77) (DQA1_HUMAN)search ,
P01909 (78-206) (DQA1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
192 94%
B HLA class II histocompatibility antigen, DQ beta 1 chain P01920 (33-224) (DQB1_HUMAN)search Homo sapienssearch < 90% 215 80%
D HLA class II histocompatibility antigen, DQ beta 1 chain P01920 (33-224) (DQB1_HUMAN)search Homo sapienssearch < 90% 215 80%
E T-CELL RECEPTOR, SP3.4 ALPHA CHAIN K7N5N2 (1-207) (K7N5N2_HUMAN)search Homo sapienssearch 100% 207 90%
G T-CELL RECEPTOR, SP3.4 ALPHA CHAIN K7N5N2 (1-207) (K7N5N2_HUMAN)search Homo sapienssearch 100% 207 90%
F T-CELL RECEPTOR, SP3.4 BETA CHAIN P01850 (1-130) (TRBC1_HUMAN)search Homo sapienssearch < 90% 245 99%
H T-CELL RECEPTOR, SP3.4 BETA CHAIN P01850 (1-130) (TRBC1_HUMAN)search Homo sapienssearch < 90% 245 99%
I Peptide from Alpha/beta-gliadin MM1 P18573 (243-260) (GDA9_WHEAT)search Triticum aestivumsearch < 90% 18 72%
J Peptide from Alpha/beta-gliadin MM1 P18573 (243-260) (GDA9_WHEAT)search Triticum aestivumsearch < 90% 18 72%


This entry contains 5 unique UniProt proteins:

UniProt accession Name Organism PDB
P01909 (24 - 77) HLA class II histocompatibility antigen, DQ alpha 1 chain Homo sapiens
P01920 (33 - 224) HLA class II histocompatibility antigen, DQ beta 1 chain Homo sapiens
K7N5N2 (1 - 207) T-CELL RECEPTOR, SP3.4 ALPHA CHAIN Homo sapiens
P01850 (1 - 130) T-CELL RECEPTOR, SP3.4 BETA CHAIN Homo sapiens
P18573 (243 - 260) Peptide from Alpha/beta-gliadin MM1 Triticum aestivum

Chain Structural classification (CATH) Sequence family (Pfam)
A, C Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, D Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
E, G Immunoglobulinssearch
F, H Immunoglobulinssearch Immunoglobulin C1-set domainsearch
I, J

Chain ID Biological process (GO) Cellular component (GO)
A, C (P01909) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch
B, D (P01920) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A, C MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, D MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
E, G search Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
F, H Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
I, J