4gbx Summary details

pdbe.org/4gbx/summary_details
spacer Crystal structure of an immune complex at pH 6.5
Summary
Header IMMUNE SYSTEMsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 20.04%, Free R-factor: 25.04%, Spacegroup: P 21 21 21
Released 16/01/2013, deposition: 28/07/2012, last revision: 16/01/2013
Authors Sethi, D.K.search; Pos, W.search; Wucherpfennig, K.W.search
Primary citation Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
CELL(CAMBRIDGE,MASS.)search vol:151, pag:1557-1568 (2012) [PubMed 23260142 ]search
Keywords immune complexsearch, peptide loadingsearch, peptide editingsearch, antigen presentationsearch, IMMUNE SYSTEMsearch
Organism Homo sapiens(human) 9606search(C D A B),synthetic construct 32630search(E)
UniProt P28067search (C)
P28068search (D)
P01903search (A)
P04229search (B)
Solvent A, B, C, D, E
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
C HLA class II histocompatibility antigen, DM alpha chain Protein P28067 (DMA_HUMAN)search
203 93%
D HLA class II histocompatibility antigen, DM beta chain Protein P28068 (DMB_HUMAN)search
199 95%
A HLA class II histocompatibility antigen, DR alpha chain Protein P01903 (DRA_HUMAN)search
191 94%
B HLA class II histocompatibility antigen, DRB1-1 beta chain Protein P04229 (2B11_HUMAN)search
208 90%
E synthetic peptide Protein
10 100%
Heterogens
Chain Id Name Ligands
C, A SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
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