4gbx Summary

pdbe.org/4gbx
spacer

Crystal structure of an immune complex at pH 6.5

The structure was published by Pos, W., Sethi, D.K., Call, M.J., et al., Anders, A.K., Pyrdol, J., and Wucherpfennig, K.W., in 2012 in a paper entitled "Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This entry contains 13 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C HLA class II histocompatibility antigen, DM alpha chain P28067 (27-225) (DMA_HUMAN)search Homo sapienssearch < 90% 203 93%
D HLA class II histocompatibility antigen, DM beta chain P28068 (19-211) (DMB_HUMAN)search Homo sapienssearch < 90% 199 95%
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-216) (DRA_HUMAN)search Homo sapienssearch < 90% 191 94%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-220) (2B11_HUMAN)search Homo sapienssearch < 90% 208 90%
E synthetic peptide Not available
synthetic constructsearch Not available 10 100%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P28067 (27 - 225) HLA class II histocompatibility antigen, DM alpha chain Homo sapiens
P28068 (19 - 211) HLA class II histocompatibility antigen, DM beta chain Homo sapiens
P01903 (26 - 216) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 220) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens

Chain Sequence family (Pfam)
C Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
D Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
A Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
E

Chain ID Biological process (GO) Cellular component (GO)
C (P28067) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
D (P28068) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch
A (P01903) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
B (P04229) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch

Chain InterPro annotation
C MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
D MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
E