4gbq Summary

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SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, 15 STRUCTURES

The structure was published by Wittekind, M., Mapelli, C., Lee, V., et al., Friedrichs, M.S., Meyers, C.A., and Mueller, L., in 1997 in a paper entitled "Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GRB2 and SOS-1.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GRB2 Q60631 (1-59) (GRB2_MOUSE)search Mus musculussearch < 90% 74 77%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q60631 (1 - 59) GRB2 Mus musculus
Q62245 (1135 - 1144) SOS-1 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch SH3 domainsearch
Chain InterPro annotation
A SH3 domainsearch Spectrin alpha chain, SH3 domainsearch