4g9c Summary


Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor

The structure was published by Wenglowsky, S., Moreno, D., Laird, E.R., et al., Rudolph, J., Sturgis, H.L., and Voegtli, W.C., in 2012 in a paper entitled "Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase B-raf.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase B-raf P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 86%
B Serine/threonine-protein kinase B-raf P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (432 - 726) Serine/threonine-protein kinase B-raf Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P15056) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch regulation of signal transductionsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch