4g83 Summary

pdbe.org/4g83
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Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element

The structure was published by Ethayathulla, A.S. and Viadiu, H., in 2013 in a paper entitled "Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.0 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely dna and Tumor protein p73.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor protein p73 O15350 (115-312) (P73_HUMAN)search Homo sapienssearch < 90% 210 94%
B Tumor protein p73 O15350 (115-312) (P73_HUMAN)search Homo sapienssearch < 90% 210 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O15350 (115 - 312) Tumor protein p73 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Immunoglobulin-likesearch P53 DNA-binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (O15350) sequence-specific DNA binding transcription factor activitysearch transcription regulatory region DNA bindingsearch DNA bindingsearch regulation of transcription, DNA-templatedsearch apoptotic processsearch nucleussearch

Chain InterPro annotation
A, B p53 tumour suppressor familysearch p53-like transcription factor, DNA-bindingsearch p53, DNA-binding domainsearch p53/RUNT-type transcription factor, DNA-binding domainsearch