Crystal structure of EGFR kinase in complex with BIBW2992
The structure was published by Solca, F., Dahl, G., Zoephel, A., et al., Himmelsbach, F., Haaksma, E., and Adolf, G.R., in 2012 in a paper entitled "Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Epidermal growth factor receptor. This molecule has the UniProt identifier P00533 (EGFR_HUMAN). The sample contained 330 residues which is < 90% of the natural sequence. Out of 330 residues 307 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: