4g50 Summary

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Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168

The structure was published by Begley, D.W., Fox, D., Jenner, D., et al., Sarkar-Tyson, M., Edwards, T.E., and Lorimer, D.D., in 2014 in a paper entitled "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase Q12306 (13-98) (SMT3_YEAST)search ,
Q3JK38 (2-113) (Q3JK38_BURP1)search
Saccharomyces cerevisiae S288csearch ,
Burkholderia pseudomallei 1710bsearch
95% ,
97%
209 91%
B Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase Q12306 (13-98) (SMT3_YEAST)search ,
Q3JK38 (2-113) (Q3JK38_BURP1)search
Saccharomyces cerevisiae S288csearch ,
Burkholderia pseudomallei 1710bsearch
95% ,
97%
209 91%


Chain Sequence family (Pfam)
A, B (Q12306) PF00240: Ubiquitin familysearch
A, B (Q3JK38) PF00254: FKBP-type peptidyl-prolyl cis-trans isomerasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q12306Q3JK38) protein foldingsearch protein peptidyl-prolyl isomerizationsearch metal ion bindingsearch isomerase activitysearch peptidyl-prolyl cis-trans isomerase activitysearch

Chain InterPro annotation
A, B Ubiquitin-likesearch Peptidyl-prolyl cis-trans isomerase, FKBP-type, domainsearch Rad60/SUMO-like domainsearch Peptidyl-prolyl cis-trans isomerase, FKBP-typesearch Ubiquitin-related domainsearch