4g3y Summary

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Crystal structure of TNF-alpha in complex with Infliximab Fab fragment

The structure was published by Liang, S.Y., Dai, J.X., Hou, S., et al., Rao, Z., Guo, Y.J., and Lou, Z.Y., in 2013 in a paper entitled "Structural basis for treating tumor necrosis factor alpha (TNFalpha)-associated diseases with the therapeutic antibody infliximab" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely infliximab Fab L, infliximab Fab H, and Tumor necrosis factor.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L infliximab Fab L Not available
Homo sapienssearch Not available 214 100%
H infliximab Fab H Not available
Homo sapienssearch Not available 226 97%
C Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) Tumor necrosis factor Homo sapiens

Chain Sequence family (Pfam)
L
H
C TNF(Tumour Necrosis Factor) familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
C (P01375) tumor necrosis factor receptor bindingsearch membranesearch immune responsesearch

Chain InterPro annotation
L Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch