Human topoisomerase iibeta in complex with DNA and ametantrone
The structure was published by Wu, C.C., Li, Y.C., Wang, Y.R., Li, T.K., and Chan, N.L., in 2013 in a paper entitled "On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.696 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), and DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3').
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterohexamers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: