spacer Human topoisomerase iibeta in complex with DNA and ametantrone
Accession Q02880search
Keywords Complete proteome, Metal-binding, Nucleus, DNA-binding, Nucleotide-binding, Phosphoprotein, Isomerase, Acetylation, Alternative splicing, Magnesium, Reference proteome, 3D-structure, Cytoplasm, Topoisomerase, ATP-binding
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Polymers A B
Enzyme nomenclature
EC number ExPASy BRENDA search
Polymers B, A
Name DNA topoisomerase (ATP-hydrolysing)
Comment The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC DNA topoisomerase).