Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine
The structure was published by Lucas, M.C., Goldstein, D.M., Hermann, J.C., et al., Xie, W., Zhang, X., and Liao, C., in 2012 in a paper entitled "Rational design of highly selective spleen tyrosine kinase inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein kinase SYK. This molecule has the UniProt identifier P43405 (KSYK_HUMAN). The sample contained 291 residues which is < 90% of the natural sequence. Out of 291 residues 266 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: