› 4fx3

X-ray diffraction
2.75Å resolution

Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor

Released:
DOI: 10.2210/pdb4fx3/pdb
PDB entry 4fx3 coloured by chain, front view.
PDB entry 4fx3 coloured by chain, side view.
PDB entry 4fx3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148886 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 258 amino acids
Theoretical weight: 29.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20248 (Residues: 175-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

2 bound ligands:
Ligand 60K 2 x 60K
Ligand DTT 3 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21
Unit cell:
a: 70.661Å b: 163.623Å c: 72.609Å
α: 90° β: 106.78° γ: 90°
R-values:
R R work R free
0.192 0.19 0.24
Expression system: Spodoptera frugiperda

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