4fu0 Summary

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Crystal Structure of VanG D-Ala:D-Ser Ligase from Enterococcus faecalis

The structure was published by Meziane-Cherif, D., Saul, F.A., Haouz, A., and Courvalin, P., in 2012 in a paper entitled "Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of D-alanine--D-alanine ligase 7.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-alanine--D-alanine ligase 7 Q6WRY5 (1-349) (Q6WRY5_ENTFL)search Enterococcus faecalissearch 100% 357 96%
B D-alanine--D-alanine ligase 7 Q6WRY5 (1-349) (Q6WRY5_ENTFL)search Enterococcus faecalissearch 100% 357 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q6WRY5 (1 - 349) D-alanine--D-alanine ligase 7 Enterococcus faecalis

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q6WRY5) Rossmann foldsearch, ATP-grasp fold, B domainsearch, ATP-grasp fold, A domainsearch PF01820: D-ala D-ala ligase N-terminussearch, PF07478: D-ala D-ala ligase C-terminussearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q6WRY5) nucleotide bindingsearch D-alanine-D-alanine ligase activitysearch magnesium ion bindingsearch manganese ion bindingsearch ATP bindingsearch catalytic activitysearch metal ion bindingsearch ligase activitysearch peptidoglycan biosynthetic processsearch cell wall organizationsearch regulation of cell shapesearch cytoplasmsearch

Chain InterPro annotation
A, B D-alanine--D-alanine ligase/VANA/B/C, conserved sitesearch D-alanine--D-alanine ligasesearch D-alanine--D-alanine ligase, C-terminalsearch D-alanine--D-alanine ligase, N-terminal domainsearch ATP-grasp foldsearch ATP-grasp fold, subdomain 1search ATP-grasp fold, subdomain 2search Pre-ATP-grasp domainsearch