4frc Summary

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Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide

A publication describing this structure is not available. The depositing authors are Di Pizio, A.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 0.98 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) response to organic substancesearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch bicarbonate transportsearch cellular response to fluid shear stresssearch one-carbon metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch response to zinc ionsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch response to steroid hormonesearch regulation of chloride transportsearch response to pHsearch secretionsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch kidney developmentsearch cytosolsearch axonsearch cytoplasmsearch myelin sheathsearch basolateral plasma membranesearch apical part of cellsearch plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch microvillussearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch