4frc Summary

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Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide

A publication describing this structure is not available. The depositing authors are Di Pizio, A.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 0.98 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch one-carbon metabolic processsearch regulation of intracellular pHsearch cellular response to fluid shear stresssearch positive regulation of cellular pH reductionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch response to estrogensearch regulation of chloride transportsearch response to steroid hormonesearch kidney developmentsearch response to pHsearch response to organic substancesearch cytosolsearch apical part of cellsearch extracellular vesicular exosomesearch cytoplasmsearch plasma membranesearch microvillussearch extracellular spacesearch membranesearch myelin sheathsearch axonsearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch