4fqx Summary

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Crystal structure of HLA-DM bound to HLA-DR1

The structure was published by Pos, W., Sethi, D.K., Call, M.J., et al., Anders, A.K., Pyrdol, J., and Wucherpfennig, K.W., in 2012 in a paper entitled "Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.599 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This entry contains 11 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C HLA class II histocompatibility antigen, DM alpha chain P28067 (27-225) (DMA_HUMAN)search Homo sapienssearch < 90% 203 91%
D HLA class II histocompatibility antigen, DM beta chain P28068 (19-211) (DMB_HUMAN)search Homo sapienssearch < 90% 199 95%
E Synthetic peptide Not available
Not available Not available 11 63%
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-216) (DRA_HUMAN)search Homo sapienssearch < 90% 191 94%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-221) (2B11_HUMAN)search Homo sapienssearch < 90% 208 89%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P28067 (27 - 225) HLA class II histocompatibility antigen, DM alpha chain Homo sapiens
P28068 (19 - 211) HLA class II histocompatibility antigen, DM beta chain Homo sapiens
P01903 (26 - 216) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 221) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens

Chain Sequence family (Pfam)
C Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
D Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
E
A Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch

Chain ID Cellular component (GO) Biological process (GO)
C (P28067) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch
D (P28068) MHC class II protein complexsearch membranesearch immune responsesearch antigen processing and presentationsearch
A (P01903) MHC class II protein complexsearch membranesearch antigen processing and presentationsearch immune responsesearch
B (P04229) MHC class II protein complexsearch membranesearch antigen processing and presentationsearch immune responsesearch

Chain InterPro annotation
C MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
D MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
E
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch