› › Structure analysis

Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate

X-ray diffraction
3Å resolution
PDB entry 4fpb coloured by chain, front view.
PDB entry 4fpb coloured by chain, side view.
PDB entry 4fpb coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: Hexokinase-1
hide full assembly name
Multimeric state: homo dimer
Accessible surface area: 69263.26 Å2
Buried surface area: 6217.61 Å2
Dissociation area: 1,807.19 Å2
Dissociation energy (ΔGdiss): -4.07 kcal/mol
Dissociation entropy (TΔSdiss): 16.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148564
Assembly 2 (preferred)
Download    3D Visualisation
Assembly Name: Hexokinase-1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 36399.68 Å2
Buried surface area: 1319.07 Å2
Dissociation area: 144.71 Å2
Dissociation energy (ΔGdiss): -4.48 kcal/mol
Dissociation entropy (TΔSdiss): 2.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148563
Assembly 3
Download    3D Visualisation
Assembly Name: Hexokinase-1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 36477.97 Å2
Buried surface area: 1284.15 Å2
Dissociation area: 121.86 Å2
Dissociation energy (ΔGdiss): -5.18 kcal/mol
Dissociation entropy (TΔSdiss): 2.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148563

Macromolecules

Hexokinase-1
Chains: A, B
Length: 917 amino acids
Theoretical weight: 102.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-917; Coverage: 100%)
Gene name: HK1
Pfam:
InterPro:
CATH:
Hexokinase-1 in PDB entry 4fpb, assembly 2, front view.
Hexokinase-1 in PDB entry 4fpb, assembly 2, side view.
Hexokinase-1 in PDB entry 4fpb, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links