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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(Furan-2-ylmethyl)ammonio]sulfonate

Source organism: Streptococcus pneumoniae
Biochemical function: exo-alpha-sialidase activity
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13088
Domain description: BNR repeat-like domain
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of Pfam domain PF13088 (BNR repeat-like domain) in Sialidase B. Showing 1 copy in chain A.

PF02012
Domain description: BNR/Asp-box repeat
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of Pfam domain PF02012 (BNR/Asp-box repeat) in Sialidase B. Showing 1 copy in chain A.

PF02973
Domain description: Sialidase, N-terminal domain
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of Pfam domain PF02973 (Sialidase, N-terminal domain) in Sialidase B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011040
Domain description: Sialidase
Occurring in:
  1. Sialidase B
IPR023364
Domain description: Trans-sialidase, domain 3
Occurring in:
  1. Sialidase B
IPR002860
Domain description: BNR repeat
Occurring in:
  1. Sialidase B
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Sialidase B
IPR026856
Domain description: Sialidase family
Occurring in:
  1. Sialidase B
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Sialidase B
IPR004124
Domain description: Glycoside hydrolase, family 33, N-terminal
Occurring in:
  1. Sialidase B

Structure domains

CATH CATH domains
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Sialidase B. Showing 1 copy in chain A.
2.40.220.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Intramolecular trans-sialidase; domain 3
Homology: Intramolecular Trans-sialidase; Domain 3
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of CATH domain 2.40.220.10 (Intramolecular trans-sialidase; domain 3) in Sialidase B. Showing 1 copy in chain A.
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Sialidase B
The deposited structure of PDB entry 4fp3 contains 1 copy of CATH domain 2.60.120.200 (Jelly Rolls) in Sialidase B. Showing 1 copy in chain A.

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